
High Resolution Lightfield Microscopy
Lightfield Microscopy for Zebrafish Brain Imaging
FPGA Hardware Architecture
ASIC Design
UI & Data Visualization
GUI Development
Lotus
Overview
Light-field microscopy can capture rich 3D activity, but traditional systems hit data-rate and synchronization limits long before whole-brain experiments. Lotus removes those bottlenecks. LeafLabs designed a parallel acquisition architecture that ingests and synchronizes streams from high-speed sCMOS sensors, built on a bank of custom FPGA hardware (Willow-based), tightly coupled firmware, and a host acquisition stack. Researchers get deterministic timing, real-time health monitoring, and a UI built for experiments—not demos. The result is a practical platform that delivers a ~100× combined improvement in spatial and temporal resolution, enabling whole-brain imaging at cellular precision and turning previously theoretical experiments into repeatable protocols.
Lotus
The Challenge
Lotus
The Solution
FPGA Hardware Architecture ASIC Design RTL/Firmware High-Speed Acquisition SCMOS Integration UI/Monitoring Data Visualization Opto-Mechanical Integration
Lotus
Performance Results
100× boost in combined spatial and temporal resolution.
Sustained 125 Gbps acquisition bandwidth.
Simultaneous neurons captured in real time across the zebrafish brain.
Together, these advances let researchers observe whole-brain activity at unprecedented speed, scale, and fidelity.
Lotus
Publications & Info
MIT News
Study: Zebrafish are smarter than we thought.
Synthetic Neurobiology Group.
Imaging the voltage of neurons distributed across entire brains of larval zebrafish.
MIT McGovern Institute.
New method visualizes groups of neurons as they compute.
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